Phenotypes Associated with This Genotype

Genotype
MGI:5294923

• Allelic Composition: Crlf2^tm1Wjl/Crlf2^tm1Wjl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:175844 )

• in DSS-treated mice

digestive/alimentary system

colitis ( J:175844 )

• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice

• mice reconstituted with wild-type bone marrow exhibit recovery from DSS-induced colitis

• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis

immune system

colitis ( J:175844 )

• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice

• mice reconstituted with wild-type bone marrow exhibit recovery from DSS-induced colitis

• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:175844 )

• in DSS-treated mice