Phenotypes Associated with This Genotype

Genotype
MGI:5294675

• Allelic Composition: Scn3b^tm1Clhh/Scn3b^tm1Clhh
• Genetic Background: 129S/SvEv-Scn3b^tm1Clhh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

irregular heartbeat ( J:177262 )

• programmed electrical stimulation ventricular tachycardia is increased compared to in wild-type mice

abnormal heart electrocardiography waveform feature ( J:177262 )

• endocardial action potential durations values are shorter than in wild-type mice

• ventricular effective refractory period is shorter than in wild-type mice

• however, mice exhibit no change in initial conduction latency and delta action potential durations at 90% repolarization

abnormal myocardial fiber physiology ( J:177262 )

• maximum value of the peak sodium current density is smaller than in wild-type cells

• peak sodium current densities are smaller than in wild-type cells

• the inactivation curve of the sodium channels is shifted in the negative direction compared to in wild-type cell

• however, mice exhibit no change in the activation function of sodium channels and sodium channel recovery from inactivation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Brugada syndrome 7		DOID:0110224	OMIM:613120	J:177262