Phenotypes Associated with This Genotype

Genotype
MGI:5294247

• Allelic Composition: Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:176519 )

• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

increased CD4-positive, alpha-beta T cell number ( J:176519 )

• mice exhibit increased positive selection of thymic and peripheral T cells compared with wild-type mice

hematopoietic system

increased T cell proliferation ( J:176519 )

• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

increased CD4-positive, alpha-beta T cell number ( J:176519 )

• mice exhibit increased positive selection of thymic and peripheral T cells compared with wild-type mice

cellular

increased T cell proliferation ( J:176519 )

• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation