Mouse Genome Informatics

involves: 129P2/OlaHsd * C57BL/6J
phenotype observed in females
phenotype observed in males
N normal phenotype
• resident males show a shorter latency to attack and attack for a longer duration with a higher frequency
• spend more time in the center of an open field and spend more time in the open arms of a plus maze compared to controls
• fail to show a preference for a novel mouse
• decrease in interaction with a novel object compared to controls
• context freezing response is significantly reduced
• cued fear conditioning response is reduced after a 48 h retention delay
• pups are more scattered in the home cage
• show a significantly shorter duration of crouching to keep the pups warm and to nurse them
• show little nest building activity and build shallower nest compared to controls
• males display persistent interest when presented with the same female indicating a failure to develop social memory
• fail to show a preference for a novel mouse
• in an open field test for social versus inanimate preference, mice show no significant difference in time spent interacting with the social or inanimate targets unlike controls
• in a sociability test for social versus empty preference, mice show a significant decrease in interaction with the social target compared to controls

nervous system
• in the cortices at 13 weeks of age

• no defect in olfaction is detected

Mouse Models of Human Disease
Autism 209850 J:176051