Mouse Genome Informatics
tg
    Tg(tetO-TAg)2-5Hiwa/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• die at 18-28 weeks of age

tumorigenesis
• all mutants have bilateral large adrenal tumors (J:156984)
• pathological analysis indicates that tumors are consistent with adrenal neuroblastoma (J:156984)
• tumors secrete dopamine and some secrete noradrenalin or adrenaline (J:156984)
• mice exhibit tumors resembling adrenal neuroblastoma not pheochromocytoma (J:175962)
• beginning at 13 weeks of age, mutants develop carcinoma of the adrenal gland

endocrine/exocrine glands
• mild hyperplasia in the adrenal medulla is seen by 5 and 9 weeks of age

cardiovascular system
N
• mutants exhibit normal blood pressure (J:175962)

Mouse Models of Human Disease
OMIM IDRef(s)
Neuroblastoma, Susceptibility to 256700 J:156984 , J:175962