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Phenotypes Associated with This Genotype
Genotype
MGI:5292662
Allelic
Composition
Tg(tetO-TAg)2-5Hiwa/0
Genetic
Background
involves: C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• all mutants have bilateral large adrenal tumors (J:156984)
• pathological analysis indicates that tumors are consistent with adrenal neuroblastoma (J:156984)
• tumors secrete dopamine and some secrete noradrenalin or adrenaline (J:156984)
• mice exhibit tumors resembling adrenal neuroblastoma not pheochromocytoma (J:175962)

mortality/aging
• die at 18-28 weeks of age

neoplasm
• beginning at 13 weeks of age, mutants develop carcinoma of the adrenal gland
• all mutants have bilateral large adrenal tumors (J:156984)
• pathological analysis indicates that tumors are consistent with adrenal neuroblastoma (J:156984)
• tumors secrete dopamine and some secrete noradrenalin or adrenaline (J:156984)
• mice exhibit tumors resembling adrenal neuroblastoma not pheochromocytoma (J:175962)

endocrine/exocrine glands
• mild hyperplasia in the adrenal medulla is seen by 5 and 9 weeks of age
• beginning at 13 weeks of age, mutants develop carcinoma of the adrenal gland

cardiovascular system
N
• mutants exhibit normal blood pressure

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuroblastoma, Susceptibility to 256700 J:156984 , J:175962


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory