Mouse Genome Informatics
hm
    Zdhhc17Gt(RRJ233)Byg/Zdhhc17Gt(RRJ233)Byg
FVB.129P2-Zdhhc17Gt(RRJ233)Byg
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• in the striatum at E14.5
• at 1, 3, and 12 months of age
• decreased volume without a change in microglial or astrocyte numbers
• non-progressive reduction observed as early as E17.5
• at E14.5, cell death in the striatum is increased compared to in wild-type mice
• however, striatum volume at E14.5 is normal
• decreased volume
• of medium spiny neurons
• medium spiny neurons contain fewer total and excitatory synapses in the striata compared to in wild-type mice

behavior/neurological
• on a accelerating or fixed rotarod
• swim speed is reduced compared to in wild-type mice

growth/size

cellular
• in the striatum at E14.5

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:175800