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Phenotypes Associated with This Genotype
Genotype
MGI:5292519
Allelic
Composition
Zdhhc17Gt(RRJ233)Byg/Zdhhc17Gt(RRJ233)Byg
Genetic
Background
FVB.129P2-Zdhhc17Gt(RRJ233)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc17Gt(RRJ233)Byg mutation (0 available); any Zdhhc17 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the striatum at E14.5
• at 1, 3, and 12 months of age
• decreased volume without a change in microglial or astrocyte numbers
• non-progressive reduction observed as early as E17.5
• at E14.5, cell death in the striatum is increased compared to in wild-type mice
• however, striatum volume at E14.5 is normal
• decreased volume
• of medium spiny neurons
• medium spiny neurons contain fewer total and excitatory synapses in the striata compared to in wild-type mice

behavior/neurological
• on a accelerating or fixed rotarod
• swim speed is reduced compared to in wild-type mice

growth/size/body

cellular
• in the striatum at E14.5

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:175800


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory