Phenotypes Associated with This Genotype

Genotype
MGI:5292347

• Allelic Composition: Rad21l^tm1Amp/Rad21l^tm1Amp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased oocyte number ( J:176168 )

♀

azoospermia ( J:176168 )

♂ • mice lack spermatozoa in the epididymides

abnormal female meiosis ( J:176168 )

♀ • pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells

abnormal male meiosis ( J:176168 )

♂ • spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells

♂ • okadaic acid-treated spermatocytes exhibit unattached univalents unlike in similarly treated wild-type spermatocytes

abnormal synaptonemal complex ( J:176168 )

• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells

• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells

abnormal male germ cell apoptosis ( J:176168 )

♂ • by stage IV of spermatogenesis

decreased mature ovarian follicle number ( J:176168 )

♀

absent primordial ovarian follicles ( J:176168 )

♀

ovary atrophy ( J:176168 )

♀

ovary fibrosis ( J:176168 )

♀ • fibrotic

small testis ( J:176168 )

♂

arrest of spermatogenesis ( J:176168 )

♂ • at stage IV

arrest of male meiosis ( J:176168 )

♂ • at zygotene

reduced female fertility ( J:176168 )

♀ • female mice produce fewer pups per litter compared with wild-type female mice

decreased litter size ( J:176168 )

• female mice produce fewer pups per litter compared with wild-type female mice

male infertility ( J:176168 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:176168 )

• in spermatocytes

cellular

decreased oocyte number ( J:176168 )

♀

azoospermia ( J:176168 )

♂ • mice lack spermatozoa in the epididymides

abnormal telomere morphology ( J:176168 )

• in spermatocytes, telomere attachement to the nuclear envelope is partially misregulated compared to in wild-type spermatocytes

abnormal female meiosis ( J:176168 )

♀ • pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells

abnormal male meiosis ( J:176168 )

♂ • spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells

♂ • okadaic acid-treated spermatocytes exhibit unattached univalents unlike in similarly treated wild-type spermatocytes

arrest of male meiosis ( J:176168 )

♂ • at zygotene

abnormal synaptonemal complex ( J:176168 )

• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells

• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells

abnormal male germ cell apoptosis ( J:176168 )

♂ • by stage IV of spermatogenesis

abnormal double-strand DNA break repair ( J:176168 )

• in spermatocytes

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:176168 )

♀

absent primordial ovarian follicles ( J:176168 )

♀

ovary atrophy ( J:176168 )

♀

ovary fibrosis ( J:176168 )

♀ • fibrotic

small testis ( J:176168 )

♂