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Phenotypes Associated with This Genotype
Genotype
MGI:5292247
Allelic
Composition		 Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (4 available); any Psen1 mutation (61 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:175901 )
• mice accumulate more plaques than in Psen1tm1.1Tcs/Psen1tm1.1Tcs Tg(APPSWE)2576Kha mice

homeostasis/metabolism
amyloid beta deposits ( J:175901 )
• mice accumulate more plaques than in Psen1tm1.1Tcs/Psen1tm1.1Tcs Tg(APPSWE)2576Kha mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory