Phenotypes Associated with This Genotype

Genotype
MGI:5292246

• Allelic Composition: Psen1^tm1.1Tcs/Psen1^tm1.1Tcs; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:175901 )

• at 3 to 4 months in a Y-maze test

nervous system

astrocytosis ( J:175901 )

• at 9 months

amyloid beta deposits ( J:175901 )

• beginning at 6 months, earlier than in Tg(APPSWE)2576Kha mice at 12 months

• fewer plaques than in Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSWE)2576Kha mice

homeostasis/metabolism

amyloid beta deposits ( J:175901 )

• beginning at 6 months, earlier than in Tg(APPSWE)2576Kha mice at 12 months

• fewer plaques than in Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSWE)2576Kha mice

cellular

astrocytosis ( J:175901 )

• at 9 months