Phenotypes Associated with This Genotype

Genotype
MGI:5292219

• Allelic Composition: Tctn2^tm1.1Reit/Tctn2^tm1.1Reit
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

absent embryonic cilia ( J:176174 )

abnormal rostral-caudal axis patterning ( J:176174 )

• variable curvature

abnormal limb mesenchyme morphology ( J:176174 )

• cilia on limb bud mesenchyme are reduced in number compared to in control mice

• however, cilia morphology is normal

abnormal embryonic neuroepithelium morphology ( J:176174 )

• cilia are scarse in the neural tube compared to in control mice

• neural tube cilia are short and bulbous unlike in control mice

absent floor plate ( J:173396 )

open neural tube ( J:173396 )

• fully penetrant

nervous system

abnormal embryonic neuroepithelium morphology ( J:176174 )

• cilia are scarse in the neural tube compared to in control mice

• neural tube cilia are short and bulbous unlike in control mice

absent floor plate ( J:173396 )

open neural tube ( J:173396 )

• fully penetrant

exencephaly ( J:173396 )

• at E13.5

digestive/alimentary system

cleft palate ( J:173396 )

right-sided stomach ( J:173396 )

cardiovascular system

ventricular septal defect ( J:173396 )

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:176174 )

• cilia on limb bud mesenchyme are reduced in number compared to in control mice

• however, cilia morphology is normal

preaxial polydactyly ( J:173396 )

• bilateral or unilateral hindlimb

vision/eye

microphthalmia ( J:173396 )

growth/size/body

cleft palate ( J:173396 )

right-sided stomach ( J:173396 )

craniofacial

cleft palate ( J:173396 )

cellular

absent embryonic cilia ( J:176174 )