About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5291995
Allelic
Composition		 Cacna1ctm3Hfm/Cacna1ctm4Hfm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Cacna1ctm3Hfm mutation (1 available); any Cacna1c mutation (147 available)
Cacna1ctm4Hfm mutation (0 available); any Cacna1c mutation (147 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175463 )
• mice die within 3 weeks of tamoxifen treatment

muscle
abnormal muscle electrophysiology ( J:175463 )
• vetricular cardiomyocytes from tamoxifen-treated mice exhibit reduced current-voltage relation of current compared with cells from control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory