Phenotypes Associated with This Genotype

Genotype
MGI:5291830

• Allelic Composition: Pax3^{tm6.1(Pax8)Buck}/Pax3^{tm6.1(Pax8)Buck}
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:176192 )

• mice die between E13.5 and E15.5

embryo

abnormal neural crest cell migration ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

abnormal neural tube morphology ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

spina bifida ( J:176192 )

• in all mice

abnormal somite development ( J:176192 )

• disorganized

muscle

abnormal muscle precursor cell migration ( J:176192 )

• absent in forelimbs at E10.5

abnormal muscle development ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

abnormal myotome development ( J:176192 )

abnormal dermomyotome development ( J:176192 )

• in the epaxial and hypaxial dermomyotome

absent skeletal muscle ( J:176192 )

• in the limb

nervous system

abnormal neural tube morphology ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

spina bifida ( J:176192 )

• in all mice

exencephaly ( J:176192 )

abnormal dorsal root ganglion morphology ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

cellular

abnormal muscle precursor cell migration ( J:176192 )

• absent in forelimbs at E10.5

abnormal neural crest cell migration ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice