Phenotypes Associated with This Genotype

Genotype
MGI:5289970

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-SNCA)7Vle/0
• Genetic Background: involves: C3H/HeH * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:156801 )

• atrophy of hippocampal dentate gyrus neurons is seen by P21

alpha-synuclein inclusion body ( J:174555 )

• mutants fed a doxycycline diet to suppress transgene expression from E0.5 until P21 and then switched to a regular diet to induce expression show accumulation of alpha-synuclein within neurons of the septum, cingulated cortex, subthalamic nucleus, mammillary body, and brainstem, but not hippocampus at 8 months of age

behavior/neurological

behavior/neurological phenotype ( J:174555 )

N • mutants do not exhibit impaired contextual fear memory at 8 months of age