Phenotypes Associated with This Genotype

Genotype
MGI:5289954

• Allelic Composition: Trp73^tm1Fmc/Trp73⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:98958 )

• half of heterozygous mutants are moribound by 14-15 months of age

• by 2 years of age, 36 of 40 mutants had to be sacrificed or died

• mice die from not only the malignant lesions but also from the benign lesions due to such things as obstructed airways from hyperplastic or premalignant lesions in the pharynx, larynx, mouth or tongue

neoplasm

increased tumor incidence ( J:98958 )

• mutants show an increase in benign premalignant lesions such as squamous cell hyperplasia and multiple lung adenomas

• tumors undergo loss of heterozygosity

increased T cell derived lymphoma incidence ( J:98958 )

• seen in 12.5% of mice

increased lung adenoma incidence ( J:98958 )

• frequency of lung adenomas is 4 times that seen in wild-type mice

increased malignant tumor incidence ( J:98958 )

increased lung adenocarcinoma incidence ( J:98958 )

• seen in 10% of mice

increased hemangiosarcoma incidence ( J:98958 )

• seen in 12.5% of mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:98958 )

• seen in 12.5% of mice

respiratory system

increased lung adenoma incidence ( J:98958 )

• frequency of lung adenomas is 4 times that seen in wild-type mice

increased lung adenocarcinoma incidence ( J:98958 )

• seen in 10% of mice

immune system

increased T cell derived lymphoma incidence ( J:98958 )

• seen in 12.5% of mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:98958 )

• seen in 12.5% of mice