Phenotypes Associated with This Genotype

Genotype
MGI:5289945

• Allelic Composition: Trp63^tm1Fmc/Trp63⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:98958 )

• half of heterozygous mutants are moribound by 14-15 months of age

• by 2 years of age, 32 of 40 mutants had to be sacrificed or died

• mice die from not only the malignant lesions but also from the benign lesions due to such things as obstructed airways from hyperplastic or premalignant lesions in the pharynx, larynx, mouth or tongue

premature aging ( J:98958 )

• 40% of mutants exhibit increased signs of aging, developing severe degenerative disc disease of the spine between 6 and 18 months of age

neoplasm

increased tumor incidence ( J:98958 )

• mutants show an increase in benign premalignant lesions such as squamous cell hyperplasia and multiple lung adenomas

• tumors undergo loss of heterozygosity

increased lung adenoma incidence ( J:98958 )

• frequency of lung adenomas is 2.5 times that seen in wild-type mice

increased malignant tumor incidence ( J:98958 )

increased histiocytic sarcoma incidence ( J:98958 )

• seen in 20% of mice by 12 months of age

increased squamous cell carcinoma incidence ( J:98958 )

• seen in 10% of mice by 12 months of age

skeleton

intervertebral disk degeneration ( J:98958 )

• 40% of mutants develop severe degenerative disc disease of the spine between 6 and 18 months of age

• degenerative disc disease is consistent with spondylosis and is most frequent in the cervical and thoracic region

respiratory system

increased lung adenoma incidence ( J:98958 )

• frequency of lung adenomas is 2.5 times that seen in wild-type mice