Mouse Genome Informatics
hm
    Slc6a19tm1Dgen/Slc6a19tm1Dgen
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Decreased body weight in Slc6a19tm1Dgen mice

growth/size
• when fed a high protein diet
• when fed a low protein diet
• by 12 weeks of age
• when fed a low or high protein diet

digestive/alimentary system
N
• mice exhibit normal intestine morphology (J:175382)
• mice exhibit decreased sodium-dependent leucine uptake in sections of inverted intestine compared to in wild-type mice

homeostasis/metabolism
• alanine, asparagine, glycine, glutamine, isoleucine, methionine, phenylalanine, serine, threonine, and tyrosine are increased in the urine compared to in wild-type mice
• upon refeeding after fasting
• mice exhibit a blunted plasma insulin response to feeding-fasting cycle compared with wild-type mice

renal/urinary system
• alanine, asparagine, glycine, glutamine, isoleucine, methionine, phenylalanine, serine, threonine, and tyrosine are increased in the urine compared to in wild-type mice
• renal brush-border membrane vesicles (BBMVs) fail to exhibit sodium-dependent leucine uptake compared with wild-type cells
• renal BBMVs exhibit reduced sodium dependent glutamine, histidine, tryptophan, glucose, and carosine compared with wild-type cells
• renal BBMVs exhibit increased sodium-independent glutamine uptake compared with wild-type cells

adipose tissue
• when fed a high protein diet

Mouse Models of Human Disease
OMIM IDRef(s)
Hartnup Disorder; HND 234500 J:175382