Phenotypes for Edil3 Mapk11 Mapk14 MGI:5288513 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Mapk11^tm1Jsca mutation (0 available); any Mapk11 mutation (31 available)
Mapk14^tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac defects in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca embryos

mortality/aging

postnatal lethality, complete penetrance ( J:176023 )

• present in the expected numbers at E18.5 but none are found at weaning

cardiovascular system

ventricular septal defect ( J:176023 )

nervous system

nervous system phenotype ( J:176023 )

N	• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14^{tm3.1(Mapk11)Nbr} allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24