Phenotypes for Edil3 Mapk11 Mapk14 MGI:5288513 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Mapk11^tm1Jsca mutation (0 available); any Mapk11 mutation (30 available)
Mapk14^tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac defects in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca embryos

mortality/aging

postnatal lethality, complete penetrance ( J:176023 )

• present in the expected numbers at E18.5 but none are found at weaning

cardiovascular system

ventricular septal defect ( J:176023 )

nervous system

nervous system phenotype ( J:176023 )

N	• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14^{tm3.1(Mapk11)Nbr} allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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