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Phenotypes Associated with This Genotype
Genotype
MGI:5288490
Allelic
Composition
Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte mutation (1 available); any Gt(ROSA)26Sor mutation (315 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age

cellular
• mice fed doxycycline exhibit swollen cardiac mitochondria, which displace neighboring myofibrils
• some mitochondria in the soleus of doxycline-treated mice form whorls, which line the inner membrane wall
• mice fed doxycycline exhibit an absence of tetralinoeoyl-cardiolipin in cardiac samples
• mice fed doxycycline exhibit a reduction in total cardiolipin and significant accumulation of monolyso-cardiolipin at 2 months
• mice fed doxycycline exhibit an increase in monolyso-cardiolipin/cardiolipin ratio at 2 months

muscle
• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age
• skeletal muscle of doxycline-treated mice exhibits a reduction in soleus contractile strength when stimulated at >100 Hz

Mouse Models of Human Disease
OMIM ID Ref(s)
Barth Syndrome; BTHS 302060 J:176041


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory