Phenotypes Associated with This Genotype

Genotype
MGI:5288490

• Allelic Composition: Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased ventricle muscle contractility ( J:176041 )

• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age

cellular

abnormal mitochondrial morphology ( J:176041 )

• mice fed doxycycline exhibit swollen cardiac mitochondria, which displace neighboring myofibrils

• some mitochondria in the soleus of doxycline-treated mice form whorls, which line the inner membrane wall

abnormal mitochondrial physiology ( J:176041 )

• mice fed doxycycline exhibit an absence of tetralinoeoyl-cardiolipin in cardiac samples

• mice fed doxycycline exhibit a reduction in total cardiolipin and significant accumulation of monolyso-cardiolipin at 2 months

• mice fed doxycycline exhibit an increase in monolyso-cardiolipin/cardiolipin ratio at 2 months

muscle

decreased ventricle muscle contractility ( J:176041 )

• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age

impaired skeletal muscle contractility ( J:176041 )

• skeletal muscle of doxycline-treated mice exhibits a reduction in soleus contractile strength when stimulated at >100 Hz

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Barth syndrome		DOID:0050476	OMIM:302060	J:176041