Mouse Genome Informatics
ot
    Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/?
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age

cellular
• mice fed doxycycline exhibit swollen cardiac mitochondria, which displace neighboring myofibrils
• some mitochondria in the soleus of doxycline-treated mice form whorls, which line the inner membrane wall
• mice fed doxycycline exhibit an absence of tetralinoeoyl-cardiolipin in cardiac samples
• mice fed doxycycline exhibit a reduction in total cardiolipin and significant accumulation of monolyso-cardiolipin at 2 months
• mice fed doxycycline exhibit an increase in monolyso-cardiolipin/cardiolipin ratio at 2 months

muscle
• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age
• skeletal muscle of doxycline-treated mice exhibits a reduction in soleus contractile strength when stimulated at >100 Hz

Mouse Models of Human Disease
OMIM IDRef(s)
Barth Syndrome; BTHS 302060 J:176041