Phenotypes for Lta Mertk MGI:5287881 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Mertk^nmf12/Mertk^nmf12
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Lta^tm1Dvk mutation (1 available); any Lta mutation (17 available)
Mertk^nmf12 mutation (1 available); any Mertk mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:175587 )

• at P45 abnormalities are seen across the entire retina

retina photoreceptor degeneration ( J:175587 )

• accelerated degeneration compared to mice homozygous for the Mertk mutation alone

thin retina inner nuclear layer ( J:175587 )

• in the peripheral retina at 3 months of age

thin retina outer nuclear layer ( J:175587 )

• markedly thinned across the entire retina at 3 months of age

nervous system

retina photoreceptor degeneration ( J:175587 )

• accelerated degeneration compared to mice homozygous for the Mertk mutation alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24