Phenotypes Associated with This Genotype

Genotype
MGI:5287716

• Allelic Composition: Trim32^tm1Spc/Trim32^tm1Spc
• Genetic Background: involves: 129S/SvEvBrd * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle fiber morphology ( J:175798 )

• fiber splitting is observed

• shift in myosin heavy chain distribution toward a slower phenotype in the soleus muscle

centrally nucleated skeletal muscle fibers ( J:175798 )

• centrally located nuclei are observed

dystrophic muscle ( J:175798 )

• mild

behavior/neurological

decreased grip strength ( J:175798 )

• average grip strength peak tension and wire hang time are reduced

weakness ( J:175798 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2H		DOID:0110282	OMIM:254110	J:175798