Mouse Genome Informatics
tg
    Tg(Myh6*)131Lnwd/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• mutants exhibit abnormal cardiac histopathology, but do not exhibit cardiac hypertrophy at 12 weeks of age, indicating a less severe phenotype than Tg(Myh6*)140Lnwd/0 mice
• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Familial Hypertrophic, 14; CMH14 613251 J:31537