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Phenotypes Associated with This Genotype
Genotype
MGI:5286085
Allelic
Composition
Tg(Myh6*)131Lnwd/0
Genetic
Background
involves: C57BL/6 * CBA
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants exhibit abnormal cardiac histopathology, but do not exhibit cardiac hypertrophy at 12 weeks of age, indicating a less severe phenotype than Tg(Myh6*)140Lnwd/0 mice
• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Familial Hypertrophic, 14; CMH14 613251 J:31537


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory