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Phenotypes Associated with This Genotype
Genotype
MGI:5285951
Allelic
Composition
Ccdc66Gt(E021F10)Wrst/Ccdc66Gt(E021F10)Wrst
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc66Gt(E021F10)Wrst mutation (0 available); any Ccdc66 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 3 months of age the outer nuclear layer is reduced to 5-6 layers
• at 5 - 7 months of age only a thin layer remains
• at 5 - 7 months of age only a thin layer with severely shrunken photoreceptor segments remains
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• expression analysis indicates degradation of rod photoreceptors
• slowly progressive degeneration beginning around P13
• b-wave amplitude is reduced up to 70% at 1 month of age
• photopic b wave amplitude improves with age, reaching near wild-type levels until 7 months of age
• mean scotopic a-wave amplitude is decreased by up to 54%

nervous system
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• expression analysis indicates degradation of rod photoreceptors
• slowly progressive degeneration beginning around P13

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa; RP 268000 J:174954


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory