Mouse Genome Informatics
hm
    Ccdc66Gt(E021F10)Wrst/Ccdc66Gt(E021F10)Wrst
involves: 129P2/OlaHsd * C57BL/6N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• at 3 months of age the outer nuclear layer is reduced to 5-6 layers
• at 5 - 7 months of age only a thin layer remains
• at 5 - 7 months of age only a thin layer with severely shrunken photoreceptor segments remains
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• expression analysis indicates degradation of rod photoreceptors
• slowly progressive degeneration beginning around P13
• b-wave amplitude is reduced up to 70% at 1 month of age
• photopic b wave amplitude improves with age, reaching near wild-type levels until 7 months of age
• mean scotopic a-wave amplitude is decreased by up to 54%

nervous system
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• partially distorted starting at P13
• severely shrunken at 5 -7 months of age
• expression analysis indicates degradation of rod photoreceptors
• slowly progressive degeneration beginning around P13

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa; RP 268000 J:174954