Phenotypes Associated with This Genotype

Genotype
MGI:5285826

• Allelic Composition: Lgr4^tm1.1Knis/Lgr4^tm1.1Knis; Lgr5^tm2.1Cle/Lgr5^tm2.1Cle; Tg(Cyp1a1-cre)1Dwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174842 )

• in beta-napthoflavone-treated mice

digestive/alimentary system

abnormal small intestinal crypt cell proliferation ( J:174842 )

• after 5 days, beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice

• however, wild-type crypt stem cell escapers exhibit proliferation

decreased small intestinal villus size ( J:174842 )

• in beta-napthoflavone-treated mice

cellular

abnormal small intestinal crypt cell proliferation ( J:174842 )

• after 5 days, beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice

• however, wild-type crypt stem cell escapers exhibit proliferation