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Phenotypes Associated with This Genotype
Genotype
MGI:5285451
Allelic
Composition		 Adamts5tm2.2Lex/Adamts5tm2.2Lex
Genetic
Background		 B6.129S5-Adamts5tm2.2Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm2.2Lex mutation (0 available); any Adamts5 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal pain threshold ( J:175366 )
• following medial meniscal destabilization, male mice do not develop mechanical allodynia unlike similarly treated wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:175366 )
• following medial meniscal destabilization, mice do not exhibit lesions unlike similarly treated wild-type mice

immune system
decreased susceptibility to induced arthritis ( J:175366 )
• following medial meniscal destabilization, mice do not exhibit lesions unlike similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory