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Phenotypes Associated with This Genotype
Genotype
MGI:5285395
Allelic
Composition
Shank3tm1.2Bux/Shank3+
Genetic
Background
C57BL/6-Shank3tm1.2Bux
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm1.2Bux mutation (1 available); any Shank3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spine enlargement accompanying long term potentiation is impaired
• decrease in the paired pulse ratio
• reduction in the I/O curves of field excitatory postsynaptic potentials in hippocampal slices from 3-4 week old mice
• decrease in AMPA receptor mediated field potentials
• initial expression of LTP is normal but maintenance is impaired
• significantly higher frequency of miniature excitatory postsynaptic currents

behavior/neurological
• total social sniffing by the males is lower
• however, no defect in olfactory abilities are detected
• fewer ultrasonic vocalizations emitted during male-female social interactions session

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:175320


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory