Mouse Genome Informatics
ht
    Shank3tm1.2Bux/Shank3+
C57BL/6-Shank3tm1.2Bux
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• spine enlargement accompanying long term potentiation is impaired
• decrease in the paired pulse ratio
• reduction in the I/O curves of field excitatory postsynaptic potentials in hippocampal slices from 3-4 week old mice
• decrease in AMPA receptor mediated field potentials
• initial expression of LTP is normal but maintenance is impaired
• significantly higher frequency of miniature excitatory postsynaptic currents

behavior/neurological
• total social sniffing by the males is lower
• however, no defect in olfactory abilities are detected
• fewer ultrasonic vocalizations emitted during male-female social interactions session

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:175320