Phenotypes for Sox4 Sox11 Tead2 MGI:5285372 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺ Tead2^tm1Hssk/Tead2^tm1Hssk
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
Tead2^tm1Hssk mutation (1 available); any Tead2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

double outlet right ventricle ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

ventricular septal defect ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

embryo

abnormal notochord morphology ( J:175338 )

• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton

abnormal vertebrae morphology ( J:175338 )

• more severe and more frequent than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24