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Phenotypes Associated with This Genotype
Genotype
MGI:5285345
Allelic
Composition
Dnaic1b2b284Clo/Dnaic1b2b284Clo
Genetic
Background
C57BL/6J-Dnaic1b2b284Clo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnaic1b2b284Clo mutation (1 available); any Dnaic1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dextrocardia with parallel outflow tracts suggestive of DORV (confirmed by EFIC imaging).

cardiovascular system
• a spectrum of complex congenital heart disease is seen in conjunction with heterotaxy (J:216862)
• a spectrum of complex congenital heart disease is seen in conjunction with heterotaxy (J:216862)
• hypoplastic transverse arch (J:216862)
• hypoplastic transverse arch (J:216862)
• multiple ventricular septal defects (J:216862)
• multiple ventricular septal defects (J:216862)

growth/size/body
• heterotaxy where the left-right positioning of organs may be randomized (J:216862)
• heterotaxy where the left-right positioning of organs may be randomized (J:216862)

respiratory system
• airway cilia are missing the outer dynein arms (J:216862)
• airway cilia are missing the outer dynein arms (J:216862)

cellular
• cilia in tracheal epithelia show missing out dynein arm defect (J:216862)
• cilia in tracheal epithelia show missing out dynein arm defect (J:216862)
• airway cilia are missing the outer dynein arms (J:216862)
• airway cilia are missing the outer dynein arms (J:216862)
• mice exhibit immotile/slow/dyskinetic cilia with little or no net fluid flow (J:216862)
• mice exhibit immotile/slow/dyskinetic cilia with little or no net fluid flow (J:216862)

mortality/aging
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth (J:216862)
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth (J:216862)

nervous system
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth (J:216862)
• mice that survive postnatally usually die from hydrocephalus by 5-10 days after birth (J:216862)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ciliary Dyskinesia, Primary, 1; CILD1 244400 J:175213


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory