Phenotypes Associated with This Genotype

Genotype
MGI:5284902

• Allelic Composition: Pdlim5^tm1.1Chen/Pdlim5^tm1.1Chen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:175042 )

N • born in expected numbers

N • mortality is normal to two years of age

reproductive system

reproductive system phenotype ( J:175042 )

N • mice are fertile

cardiovascular system

abnormal heart morphology ( J:175042 )

increased heart weight ( J:175042 )

• heart to body weight ratio modestly increased

increased heart left ventricle size ( J:175042 )

• left ventricular internal dimension is increased after pressure overload but less wall thickening

dilated heart left ventricle ( J:175042 )

• modest but significant left ventricular enlargement at end diastole beginning at 3 months of age

• wall thickness normal

abnormal cardiovascular system physiology ( J:175042 )

dilated cardiomyopathy ( J:175042 )

• heart to body weight ratio modestly increased

abnormal blood pressure regulation ( J:175042 )

• peak positive pressure differential is slightly but significantly lower than in controls at high dobutamine concentrations

abnormal cardiac muscle contractility ( J:175042 )

• isovolumic relaxation is dramatically impaired

decreased left ventricle systolic pressure ( J:175042 )

• decreased left ventricular systolic function than in controls after transverse aortic constriction

muscle

dilated cardiomyopathy ( J:175042 )

• heart to body weight ratio modestly increased

abnormal cardiac muscle contractility ( J:175042 )

• isovolumic relaxation is dramatically impaired

abnormal Z line morphology ( J:175042 )

• wider than in controls

growth/size/body

increased heart weight ( J:175042 )

• heart to body weight ratio modestly increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:175042