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Phenotypes Associated with This Genotype
Genotype
MGI:5142261
Allelic
Composition		 Fostm3.1Wag/Fostm3.1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm3.1Wag mutation (0 available); any Fos mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-10 secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased tumor necrosis factor secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased susceptibility to endotoxin shock ( J:175064 )
• LPS-treated bone marrow macrophages exhibit increased TNF-alpha but decreased IL10 production compared with similarly treated wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory