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Phenotypes Associated with This Genotype
Genotype
MGI:5142226
Allelic
Composition		 Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-cre)16Lowl/0
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 involves: 129 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Chua mutation (1 available); any Lepr mutation (123 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:174691 )
N
• addtion of leptin to neurons reduces the frequency of spontaneous (s)IPSCs in Pomc1 neurons by about 40%, similar to the inhibition observed in control neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory