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Phenotypes Associated with This Genotype
Genotype
MGI:5142225
Allelic
Composition		 Leprtm1.1Chua/Leprtm1.1Chua
Slc32a1tm2(cre)Lowl/Slc32a1+
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Chua mutation (1 available); any Lepr mutation (123 available)
Slc32a1tm2(cre)Lowl mutation (2 available); any Slc32a1 mutation (55 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inhibitory postsynaptic currents ( J:174691 )
• addition of leptin fails to reduce the frequency of sIPSCs (spontaneous inhibitory postsynaptic currents) in Pomc1 neurons, while in control slices, the frequency is reduced by about 40%

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory