Phenotypes Associated with This Genotype

Genotype
MGI:5142146

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Slc32a1^tm2(cre)Lowl/Slc32a1⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:174691 )

• males and females exhibit a massive increase in body weight from 4 weeks of age through 7 weeks compared to controls

behavior/neurological

polyphagia ( J:174691 )

• food intake is greatly increased compared to controls

nervous system

abnormal nervous system electrophysiology ( J:174691 )

• Pomc1 neurons tend to be hyperpolarized relative to control neurons

abnormal inhibitory postsynaptic currents ( J:174691 )

• a large increase in amplitude and frequency of spontaneous IPSCs is observed in Pomc1 neurons in slice preparations from mice with conditional deletion of Lepr, indicating that deletion from presynaptic GABAergic neurons increases the inhibitory tone in Pomc1 neurons

homeostasis/metabolism

abnormal circulating glucose level ( J:174691 )

• animals have significantly elevated fed and fasting blood glucose levels

increased circulating insulin level ( J:174691 )

• animals have significantly elevated fed and fasted serum insulin levels

adipose tissue

increased total body fat amount ( J:174691 )

• animals display a massive increase in fat mass relative to controls at 10 weeks of age