Phenotypes Associated with This Genotype

Genotype
MGI:5142145

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Slc17a6^tm2(cre)Lowl/Slc17a6⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:174691 )

N • animals do not show significant changes in body weight up to 11 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:174691 )

N • food intake shows no significant difference compared to controls

nervous system

nervous system phenotype ( J:174691 )

N • deletion of Lepr in Slc17a6 neurons does not alter IPSC amplitude in Agrp neurons; IPSC frequency is decreased (not significantly) in Agrp

N • excitatory postsynaptic currents (sEPSCs and mEPSCs) in Pomc1 neurons are not affected by Lepr deletion in Slc17a6 (glutamatergic) neurons

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:174691 )

N • fed and fasted blood glucose levels are unchanged and serum insulin levels are only slightly increased in the fed state

adipose tissue

adipose tissue phenotype ( J:174691 )

N • no increase in fat mass is observed at 10 weeks