Phenotypes Associated with This Genotype

Genotype
MGI:5141748

• Allelic Composition: Tg(UPII-SV40T)9Xrw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased urinary bladder carcinoma incidence ( J:56305 )

• although mutants appear outwardly healthy at 5-8 months of age, they show features of bladder carcinoma in situ (CIS), including moderate-to-severe urothelial atypia with marked nuclear pleomophism such as giant nuclei and abundant mitotic figures

• CIS lesions do not progress to transitional cell carcinoma (TCC) by 8 months of age

renal/urinary system

increased urinary bladder carcinoma incidence ( J:56305 )

• although mutants appear outwardly healthy at 5-8 months of age, they show features of bladder carcinoma in situ (CIS), including moderate-to-severe urothelial atypia with marked nuclear pleomophism such as giant nuclei and abundant mitotic figures

• CIS lesions do not progress to transitional cell carcinoma (TCC) by 8 months of age