reproductive system
N |
• female mice exhibit normal fertility
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• at 6 weeks in the epididymis
• dramatic at 9 weeks
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• at P60
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• disorganized
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• 30% fewer cells at P45
• 70% fewer cells at P60
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• at P60
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• at 9 weeks, male mice are infertile
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• in male mice
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• at P45, fewer proliferating spermatogonia and primary spermatocytes per seminiferous tubules compared with wild-type mice
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• at 9 weeks
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• at 6 weeks
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mortality/aging
• at 9 weeks, male mice are infertile
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endocrine/exocrine glands
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• at P60
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• disorganized
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• 30% fewer cells at P45
• 70% fewer cells at P60
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• at P60
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cellular
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• at 6 weeks in the epididymis
• dramatic at 9 weeks
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