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Phenotypes Associated with This Genotype
Genotype
MGI:5141626
Allelic
Composition
Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif
Genetic
Background
C3H/HeOuJ-Tg(H2-K1-Ifnb1)10Seif
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(H2-K1-Ifnb1)10Seif mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice exhibit normal fertility
• at 6 weeks in the epididymis
• dramatic at 9 weeks
• 30% fewer cells at P45
• 70% fewer cells at P60
• at 9 weeks, male mice are infertile
• in male mice
• at P45, fewer proliferating spermatogonia and primary spermatocytes per seminiferous tubules compared with wild-type mice
• at 9 weeks
• at 6 weeks

mortality/aging
• at 9 weeks, male mice are infertile

endocrine/exocrine glands
• 30% fewer cells at P45
• 70% fewer cells at P60

cellular
• at 6 weeks in the epididymis
• dramatic at 9 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory