Phenotypes Associated with This Genotype

Genotype
MGI:5141246

• Allelic Composition: Klf5^tm1.1Jwel/Klf5^tm1.1Jwel
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:168150 )

• embryos arrested at the blastocyst stage

• heterozygous intercrosses revealed no null embryos between E6.5 and E8.5

embryo

decreased inner cell mass proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

decreased trophectoderm cell proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

failure of blastocyst to hatch from the zona pellucida ( J:168150 )

• morulae cultured failed to hatch embryos and eventually collapsed

absent blastocoele ( J:168150 )

• the majority of E3.5 mutant embryos had either no cavity or a small cavity

cellular

decreased inner cell mass proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

decreased trophectoderm cell proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages