Phenotypes Associated with This Genotype

Genotype
MGI:5140930

• Allelic Composition: Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:173602 )

N • mice exhibit normal survival

cardiovascular system

abnormal aorta morphology ( J:173602 )

• mice exhibit alterations in the ascending aorta at 2 weeks that progresses through the arch and descending aorta to affect the entire thoracic and abdominal aorta by 4 weeks unlike in wild-type mice

• mice exhibit reduced periaortic adipose compared to in wild-type mice

abnormal aorta tunica media morphology ( J:173602 )

• thickened

increased aorta wall thickness ( J:173602 )

• authors state that mice exhibit the aorta phenotype observed in mice expressing the floxed allele and Tg(Sox2-cre)1Amc

• however, aorta histology is normal in neonates

abnormal descending aorta morphology ( J:173602 )

• by 4 weeks

abnormal abdominal aorta morphology ( J:173602 )

• by 4 weeks

abnormal thoracic aorta morphology ( J:173602 )

• by 4 weeks

abnormal aortic arch morphology ( J:173602 )

• by 4 weeks

dilated aorta ( J:173602 )

• increased radius

• 2-fold dilation that reaches homeostasis without rupture or apoptosis of vascular smooth muscle cells

abnormal capillary morphology ( J:173602 )

• at P7, retinal capillary size is increased compared to in wild-type mice

• at P12, brain capillary size is increased compared to in wild-type mice

abnormal brain vasculature morphology ( J:173602 )

• reduced vessel density

abnormal retina vasculature morphology ( J:173602 )

• reduced vessel density

abnormal pericyte morphology ( J:173602 )

• pericyte coverage of brain and retinal vasculature is increased compared to in wild-type mice

vascular smooth muscle hyperplasia ( J:173602 )

• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice

increased vascular smooth muscle cell proliferation ( J:173602 )

• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice

• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures

adipose tissue

abnormal adipose tissue morphology ( J:173602 )

• mice exhibit reduced periaortic adipose compared to in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:173602 )

N • mice exhibit normal growth

muscle

vascular smooth muscle hyperplasia ( J:173602 )

• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice

increased vascular smooth muscle cell proliferation ( J:173602 )

• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice

• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures

nervous system

abnormal brain vasculature morphology ( J:173602 )

• reduced vessel density

vision/eye

abnormal retina vasculature morphology ( J:173602 )

• reduced vessel density

cellular

increased vascular smooth muscle cell proliferation ( J:173602 )

• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice

• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures