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Phenotypes Associated with This Genotype
Genotype
MGI:5140789
Allelic
Composition		 F2tm2Jld/F2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm2Jld mutation (0 available); any F2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:174629 )
• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:174629 )
• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory