Phenotypes Associated with This Genotype

Genotype
MGI:5140788

• Allelic Composition: F2^tm2Jld/F2⁺
• Genetic Background: B6.129P2-F2^tm2Jld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

decreased susceptibility to induced thrombosis ( J:174629 )

• following FeCl3 injury, mice exhibit extended time to complete vessel occlusion compared with similarly treated wild-type mice

increased bleeding time ( J:174629 )

immune system

decreased susceptibility to endotoxin shock ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

• however, LPS-treated mice exhibit no survival advantage