Phenotypes Associated with This Genotype

Genotype
MGI:5140721

• Allelic Composition: Ccdc88a^tm3.1Mat/Ccdc88a^tm3.1Mat
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:173379 )

• at P52, survival rate is 40%

nervous system

abnormal neuronal precursor cell migration ( J:173379 )

• neuroblasts fail to migrate properly and accumulate in the rostral migratory stream unlike in wild-type mice

abnormal olfactory bulb development ( J:173379 )

abnormal rostral migratory stream morphology ( J:173379 )

• neuroblasts fail to migrate properly and accumulate in the rostral migratory stream unlike in wild-type mice

growth/size/body

weight loss ( J:173379 )

• after P7 and P8

cellular

abnormal neuronal precursor cell migration ( J:173379 )

• neuroblasts fail to migrate properly and accumulate in the rostral migratory stream unlike in wild-type mice