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Phenotypes Associated with This Genotype
Genotype
MGI:5140710
Allelic
Composition		 Epb41l3tm1Bhat/Epb41l3tm1.1Bhat
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l3tm1.1Bhat mutation (0 available); any Epb41l3 mutation (46 available)
Epb41l3tm1Bhat mutation (0 available); any Epb41l3 mutation (46 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal paranode morphology ( J:173383 )
• accumulation of smooth endoplasmic reticulum in nodal-paranodal regions
abnormal paranodal axoglial junction morphology ( J:173383 )
• septate junction septa in sciatic nerves become more diffuse, most lacking electron dense granules at 1 month of age
• septa in sciatic nerves are diffuse and fuzzy at 3 months
• axolemma becomes detached from the myelin loops where septa are missing in the spinal cord

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory