Phenotypes Associated with This Genotype

Genotype
MGI:5140122

• Allelic Composition: Tg(APOE-ABCA1)30Ssf/?
• Genetic Background: C57BL/6N-Tg(APOE-ABCA1)30Ssf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:70494 )

• fasting plasma total cholesterol, cholesterol esters and free cholesterol levels are elevated as compared to controls

increased circulating HDL cholesterol level ( J:70494 )

• elevated HDL-C

increased circulating phospholipid level ( J:70494 )

increased liver cholesterol level ( J:70494 )

• increase in cholesterol and phospholipid content of bile

increased triglyceride level ( J:70494 )

• increased tryiglyceride levels only observed in males

increased cholesterol efflux ( J:70494 )

• absolute delivery of HDL-CE to liver is increased 1.5 times

abnormal apolipoprotein level ( J:70494 )

• increase in APOA-I, APOA-II and APOB levels in both males and females

abnormal circulating apolipoprotein E level ( J:70494 )

• APOE levels are increased only in males

liver/biliary system

increased liver cholesterol level ( J:70494 )

• increase in cholesterol and phospholipid content of bile