Phenotypes Associated with This Genotype

Genotype
MGI:5140118

• Allelic Composition: Gjc2^tm2.1Kwi/Gjc2⁺
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Disturbed myelin basic protein (MBP) expression accompanied by astrogliosis and microglial activation in juvenile Gjc2^tm2.1Kwi/Gjc2^tm2.1Kwi, Gjc2^tm2.1Kwi/Gjc2⁺, and Gjc2^tm1(EGFP)Kwi/Gjc2^tm1(EGFP)Kwi mice

nervous system

microgliosis ( J:174197 )

• in the cerebellar white matter at P10 but not at P90

increased oligodendrocyte number ( J:174197 )

• in the white and gray matter

abnormal oligodendrocyte physiology ( J:174197 )

• decrease in the number of cells forming networks after biocytin injections into single cells

• impairment in myelin protein synthesis

abnormal brain white matter morphology ( J:174197 )

• a few swollen and degenerating cells are seen in the optic fascicle

abnormal cerebellum morphology ( J:174197 )

• at P90 fine fibers pervading the granular layer are almost absent

behavior/neurological

decreased vertical activity ( J:174197 )

• decrease in rearing activity at 3 months of age in an open field

decreased locomotor activity ( J:174197 )

• decreased locomotion and running speed at 3 months of age in an open field

hematopoietic system

microgliosis ( J:174197 )

• in the cerebellar white matter at P10 but not at P90

immune system

microgliosis ( J:174197 )

• in the cerebellar white matter at P10 but not at P90

cellular

microgliosis ( J:174197 )

• in the cerebellar white matter at P10 but not at P90

increased oligodendrocyte number ( J:174197 )

• in the white and gray matter

abnormal oligodendrocyte physiology ( J:174197 )

• decrease in the number of cells forming networks after biocytin injections into single cells

• impairment in myelin protein synthesis