Phenotypes Associated with This Genotype

Genotype
MGI:5086228

• Allelic Composition: Glrb^spa/Glrb^spa; Tg(Eno2-Glrb)456Wha/0
• Genetic Background: involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced male fertility ( J:60037 )

♂ • not as severe as in Glrb^spa homozygotes

behavior/neurological

impaired righting response ( J:60037 )

• in 52% of mice compared with 100% of Glrb^spa homozygotes

hyperekplexia ( J:60037 )

limb grasping ( J:60037 )

• in 71% of mice compared with 100% of Glrb^spa homozygotes

tremors ( J:60037 )

• at 14 to 17 days old

muscle

muscle hypertonia ( J:60037 )

• mice exhibit a less severe spastic phenotype compared with Glrb^spa homozygotes