Phenotypes Associated with This Genotype

Genotype
MGI:5086012

• Allelic Composition: \Amer1^tm1.1Nbar/Y; \Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

large fontanelles ( J:173242 )

skeleton

abnormal bone structure ( J:173242 )

♂

increased bone volume ( J:173242 )

♂

increased osteoblast cell number ( J:173242 )

♂ • increase in the osteoblast number relative to surface area

increased trabecular bone thickness ( J:173242 )

♂

osteosclerosis ( J:173242 )

♂

abnormal skeleton development ( J:173242 )

♂

large fontanelles ( J:173242 )

increased bone mineralization ( J:173242 )

♂ • increased mineralization of cortical and trabecular bone

♂ • increased in bone mineralized surface per bone surface

♂ • however, no increase in bone width is detected

delayed fontanelle closure ( J:173242 )

♂ • wide cranial fontanelles are persistent until birth

increased bone ossification ( J:173242 )

♂ • increased bone formation rate per tissue volume