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Phenotypes Associated with This Genotype
Genotype
MGI:5086009
Allelic
Composition
Amer1tm1.1Nbar/Y
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amer1tm1.1Nbar mutation (0 available); any Amer1 mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• recapitulates appendicular skeletal phenotypes seen in germline null mice
• sharp reduction in the adipocyte content of long bones
• asymmetrical distribution of ossification centers
• increase in the proportion of early osteoblastic cells in primary bone marrow derived mesenchymal progenitor cell cultures compared to wild-type cultures indicating enhanced early osteogenic commitment
• decrease in the late differentiation of osteoblasts in primary bone marrow derived mesenchymal progenitor cell cultures
• primary bone marrow derived mesenchymal progenitor cell cultures continue to produce osteogenic cells under adipogenic conditions
• accumulation of cortical bone in adults
• increase in the osteoblast number relative to surface area
• accumulation of trabecular bone in adults
• increased bone formation rate per tissue volume
• increase in bone mineralized surface per bone surface
• increase in osteoid volume per bone volume indicates a delay in bone mineralization

adipose tissue
• sharp reduction in the adipocyte content of long bones
• severely compromised formation of oil red O-positive adipocytes in primary bone marrow derived mesenchymal progenitor cell cultures

limbs/digits/tail

cellular
• severely compromised formation of oil red O-positive adipocytes in primary bone marrow derived mesenchymal progenitor cell cultures
• increase in the proportion of early osteoblastic cells in primary bone marrow derived mesenchymal progenitor cell cultures compared to wild-type cultures indicating enhanced early osteogenic commitment
• decrease in the late differentiation of osteoblasts in primary bone marrow derived mesenchymal progenitor cell cultures
• primary bone marrow derived mesenchymal progenitor cell cultures continue to produce osteogenic cells under adipogenic conditions

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteopathia Striata with Cranial Sclerosis; OSCS 300373 J:173242


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory