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Phenotypes Associated with This Genotype
Genotype
MGI:5086009
Allelic
Composition
Amer1tm1.1Nbar/Y
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amer1tm1.1Nbar mutation (0 available); any Amer1 mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• recapitulates appendicular skeletal phenotypes seen in germline null mice
• sharp reduction in the adipocyte content of long bones
• asymmetrical distribution of ossification centers
• increase in the proportion of early osteoblastic cells in primary bone marrow derived mesenchymal progenitor cell cultures compared to wild-type cultures indicating enhanced early osteogenic commitment
• decrease in the late differentiation of osteoblasts in primary bone marrow derived mesenchymal progenitor cell cultures
• primary bone marrow derived mesenchymal progenitor cell cultures continue to produce osteogenic cells under adipogenic conditions
• accumulation of cortical bone in adults
• increase in the osteoblast number relative to surface area
• accumulation of trabecular bone in adults
• increase in osteoid volume per bone volume indicates a delay in bone mineralization
• increase in bone mineralized surface per bone surface
• increased bone formation rate per tissue volume

adipose tissue
• sharp reduction in the adipocyte content of long bones
• severely compromised formation of oil red O-positive adipocytes in primary bone marrow derived mesenchymal progenitor cell cultures

limbs/digits/tail

cellular
• severely compromised formation of oil red O-positive adipocytes in primary bone marrow derived mesenchymal progenitor cell cultures
• increase in the proportion of early osteoblastic cells in primary bone marrow derived mesenchymal progenitor cell cultures compared to wild-type cultures indicating enhanced early osteogenic commitment
• decrease in the late differentiation of osteoblasts in primary bone marrow derived mesenchymal progenitor cell cultures
• primary bone marrow derived mesenchymal progenitor cell cultures continue to produce osteogenic cells under adipogenic conditions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteopathia striata with cranial sclerosis DOID:0060886 OMIM:300373
J:173242


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory