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Phenotypes Associated with This Genotype
Genotype
MGI:5085869
Allelic
Composition
Pycardtm1Flv/Pycardtm1Flv
Genetic
Background
B6.129S5-Pycardtm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Flv mutation (0 available); any Pycard mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed or cross-fostered wild-type mice
• mice cross-fostered by wild-type dams exhibit milder colitis than noncross-fostered mice
• however, antibiotic (not oral gancyclovir, amphotericin, or albendazole and praziquantel) treatment restores wild-type levels of susceptibility to DSS-induced colitis
• in untreated mice
• in untreated mice
• in untreated mice

digestive/alimentary system
• colonic crypt hyperplasia in untreated mice
• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed or cross-fostered wild-type mice
• mice cross-fostered by wild-type dams exhibit milder colitis than noncross-fostered mice
• however, antibiotic (not oral gancyclovir, amphotericin, or albendazole and praziquantel) treatment restores wild-type levels of susceptibility to DSS-induced colitis

endocrine/exocrine glands
• colonic crypt hyperplasia in untreated mice

hematopoietic system
• in untreated mice
• in untreated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory