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Phenotypes Associated with This Genotype
Genotype
MGI:5085306
Allelic
Composition		 Cd86tm1Shr/Cd86tm1Shr
Genetic
Background		 B6.129S4-Cd86tm1Shr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd86tm1Shr mutation (9 available); any Cd86 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:57613 )
• T cells primed to myelin oligodendrocyte glycoprotein (MOG) 355-55 peptide exhibit modestly reduced proliferative responses as compared to than controls

immune system
decreased T cell proliferation ( J:57613 )
• T cells primed to myelin oligodendrocyte glycoprotein (MOG) 355-55 peptide exhibit modestly reduced proliferative responses as compared to than controls
increased interferon-gamma secretion ( J:57613 )
• lymph node cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) 355-55 peptide produce more interferon gamma than wild type cells

cellular
decreased T cell proliferation ( J:57613 )
• T cells primed to myelin oligodendrocyte glycoprotein (MOG) 355-55 peptide exhibit modestly reduced proliferative responses as compared to than controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory