Phenotypes Associated with This Genotype

Genotype
MGI:5085302

• Allelic Composition: Cd80^tm1Shr/Cd80^tm1Shr; Cd86^tm1Shr/Cd86^tm1Shr
• Genetic Background: B6.129S4-Cd80^tm1Shr Cd86^tm1Shr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell proliferation ( J:57613 )

• T cells primed by MOG 355-55 peptide exhibit markedly impaired proliferative responses as compared to controls

immune system

decreased T cell proliferation ( J:57613 )

• T cells primed by MOG 355-55 peptide exhibit markedly impaired proliferative responses as compared to controls

increased interferon-gamma secretion ( J:57613 )

• lymph node cells from mice immunized with MOG 355-55 peptide produce a greater than 30 fold increase in interferon gamma as compared to wild type cells

increased tumor necrosis factor secretion ( J:57613 )

• lymph node cells from mice immunized with MOG 355-55 peptide produce increased amounts of TNFalpha as compared to wild type cells, although the increase is limited to the first 24 hours of culture

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:57613 )

• mice do not develop clinical symptoms of EAE following stimulation by myelin oligodendrocyte glycoprotein (MOG) 355-55 peptide or by adoptive transfer

brain inflammation ( J:57613 )

• 50% of mice exhibit inflammatory lesions in meninges and CNS parenchyma as compared to 80% in wild-type following 35 day observation period after EAE induction

• inflammatory foci are limited to leptomeninges

nervous system

brain inflammation ( J:57613 )

• 50% of mice exhibit inflammatory lesions in meninges and CNS parenchyma as compared to 80% in wild-type following 35 day observation period after EAE induction

• inflammatory foci are limited to leptomeninges

cellular

decreased T cell proliferation ( J:57613 )

• T cells primed by MOG 355-55 peptide exhibit markedly impaired proliferative responses as compared to controls