Phenotypes Associated with This Genotype

Genotype
MGI:5085292

• Allelic Composition: Llgl2^{Gt(XS0846)Wtsi}/Llgl2^{Gt(XS0846)Wtsi}
• Genetic Background: B6.129P2-Llgl2^{Gt(XS0846)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:174237 )

• many pups do not survive to weaning

• reducing litter size eliminates postnatal lethality

growth/size/body

decreased birth body size ( J:174237 )

• pups that survive past weaning catch up with littermates in size

decreased fetal weight ( J:174237 )

• significant at E18.5

• first detected at E15.5

embryo

abnormal placenta labyrinth morphology ( J:174237 )

• differences in labyrinth morphology are not dependent on maternal genotype

abnormal placental labyrinth vasculature morphology ( J:174237 )

• a decrease in the surface area of fetal blood vessels at E13.5 and E14.5, but not at E11.5

abnormal placenta fetal blood space morphology ( J:174237 )

• increase in fetal lumen size

abnormal placenta intervillous maternal lacunae morphology ( J:174237 )

• increase in the percentage of large maternal lumens and decrease in the percentage of small lumens at E13.5 but not at E11.5

increased placenta intervillous maternal lacunae size ( J:174237 )

• increase in the size of maternal blood lumens

decreased placental labyrinth size ( J:174237 )

• significantly decreased in area

abnormal placental labyrinth villi morphology ( J:174237 )

• at E11.5 the syncytiotrophoblast layers I and II in the trilaminar layer contain more frequent gaps and openings than in control littermates

abnormal placental labyrinth villi branching morphogenesis ( J:174237 )

• increase in the percentage of large maternal lumens and decrease in the percentage of small lumens at E13.5 but not at E11.5 indicates a defect in branching morphogenesis of villi in the labyrinth layer

• a decrease in the trophoblast transport surface area in the labyrinth at E13.5 and E14.5

small placenta ( J:174237 )

• at E11.5 - E14.5

decreased placenta weight ( J:174237 )

• from E13.5 - E17.5

integument

integument phenotype ( J:174237 )

N • skin hemidesmosomes and overall skin morphology are normal, unlike in zebrafish with a mutation in this gene

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:174237 )

• a decrease in the surface area of fetal blood vessels at E13.5 and E14.5, but not at E11.5